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Hexakosioihexekontahexaphobia is the fear of the number 666. The reason for this such a fear is that 666 is the Number of the Beast. This word is derived from Ancient Greek roots hexakósioi, "six hundred", hexékonta, "sixty", héx, "six", and phóbos, "fear"; literally meaning "fear of six hundred sixty-six". This fear is common but it doesn't affect their lives much.

Severe sufferers may try to avoid the number at all times and need special education in school, like blocking the cable channel 666, driving to change their odometer number from 666 to 667, or changing the address from 666 to the one adjacent to it. For example, in 1989 after Ronald Reagan was elected as the U.S. president, he and his wife Nancy moved to a new home in the Bel-Air section of Los Angeles on the 666 St. Cloud Road. They soon changed their street address to 668 due to their fears of the former number.

One of the most infamous designations of the number in the traffic road numbering system is U.S. Highway 666, which proved dangerous statistically. Skeptics believe that this was due to the road being improperly designed or maintained for increasing traffic loads; however, many believed that it was actually the highway number that caused accidents and fatalities. This quickly became well aware by the public. Highway 666 changed it name to the Devil’s Highway, and then eventually to U.S. Highway 491.

The phobia is commonly portrayed in a number of horror films such as The Omen and its 2006 remake.

Number phobias
Oudenophobia (fear of 0) · Henophobia (fear of 1) · Dyophobia (fear of 2) · Triskaphobia (fear of 3) · Tetraphobia (fear of 4) · Pentaphobia (fear of 5) · Hexaphobia (fear of 6) · Heptaphobia (fear of 7) · Octophobia (fear of 8) · Enneaphobia (fear of 9) · Decaphobia (fear of 10) · Hendecaphobia (fear of 11) · Dodecaphobia (fear of 12) · Triskaidekaphobia (fear of 13) · Hexadecaphobia (fear of 16) · Heptadecaphobia (fear of 17) · Octodecaphobia (fear of 18) · Enneadecaphobia (fear of 19) · Eikositriophobia (fear of 23) · Eikosihexaphobia (fear of 26) · Triakontenneaphobia (fear of 39) · Tessarakontadyophobia (fear of 42) · Hexekontadyophobia (fear of 62) · Hexekontenneaphobia (fear of 69) · Hebdomekontahenophobia (fear of 71) · Ogdokontaheptaphobia (fear of 87) · Enenekontenneaphobia (fear of 99) · Hekatophobia (fear of 100) · Hekatohendecaphobia (fear of 111) · Hekatenenekontahenophobia (fear of 191) · Diakosioihekkaidekaphobia (fear of 216) · Diakosioipentekontaphobia (fear of 250) · Triakosioitriakontatriophobia (fear of 333) · Tetrakosioeikosiphobia (fear of 420) · Hexakosioihekkaidekaphobia (fear of 616) · Hexakosioihexekontahexaphobia (fear of 666) · Heftakosioitessarakontaheptaphobia (fear of 747) · Enniakosioihendecaphobia (fear of 911) · Enniakosioenenekontenneaphobia (fear of 999) · Tessarakontadyochilahexekontenneaphobia (fear of 42069) · Meganumerophobia (fear of large numbers) · Imparnumerophobia (fear of odd numbers) · Omalonumerophobia (fear of even numbers) · Primonumerophobia (fear of prime numbers) · Paranumerophobia (fear of irrational numbers) · Neganumerophobia (fear of negative numbers)